RVP

Drug Catalog - Product Detail

ERYTHROMYCIN OPTHALMIC OINTMENT OINT 5MG/GM 3.5GM

NDC Mfr Size Str Form
00574-4024-35 PADAGIS 3 5MG/GM OINTMENT
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PACKAGE FILES

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Generic Name
ERYTHROMYCIN
Substance Name
ERYTHROMYCIN
Product Type
HUMAN PRESCRIPTION DRUG
Route
OPHTHALMIC
Application Number
ANDA062447
Description
DESCRIPTION: Erythromycin Ophthalmic Ointment belongs to the macrolide group of antibiotics. It is basic and readily forms a salt when combined with an acid. The base, as crystals or powder, is slightly soluble in water, moderately soluble in ether, and readily soluble in alcohol or chloroform. Erythromycin ((3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-dideoxy-3- C -methyl-3- 0 -methyl-α-L- ribo -hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-ß-D- xylo -hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione) is antibiotic produced from a strain of Streptomyces erythraeus . It has the following structural formula: Each gram contains Erythromycin USP 5 mg in a sterile ophthalmic base of mineral oil and white petrolatum. Structure Image
How Supplied
HOW SUPPLIED Sterile Erythromycin Ophthalmic Ointment USP, 5 mg/g as follows: 3.5 g (1/8 oz) tamper-evident tubes NDC 0574- 4024 -35 24 x 3.5 g (1/8 oz) Hospital-Pak (for hospital use only) NDC 0574- 4024 -39 Carton of fifty (50) Unit Dose 1 g tubes NDC 0574- 4024 -50 Store at controlled room temperature 15°-30°C (59°-86°F). Avoid excessive heat. Protect from freezing.
Indications & Usage
INDICATIONS AND USAGE: For the treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by organisms susceptible to erythromycin. For prophylaxis of ophthalmia neonatorum due to N. gonorrhoeae or C. trachomatis . The effectiveness of erythromycin in the prevention of ophthalmia caused by penicillinase-producing N. gonorrheae is not established. For infants born to mothers with clinically apparent gonorrhea, intravenous or intramuscular injections of aqueous crystalline penicillin G should be given; a single dose of 50,000 units for term infants or 20,000 units for infants of low birth weight. Topical prophylaxis alone is inadequate for these infants.
Dosage and Administration
DOSAGE AND ADMINISTRATION: In the treatment of superficial ocular infections, a ribbon approximately 1 cm in length of Erythromycin Ophthalmic Ointment should be applied directly to the infected structure up to 6 times daily, depending on the severity of the infection. For prophylaxis of neonatal gonococcal or chlamydial conjunctivitis, a ribbon of ointment approximately 1 cm in length should be instilled into each lower conjunctival sac. The ointment should not be flushed from the eye following instillation. A new tube should be used for each infant.