2 DOSAGE AND ADMINISTRATION Apply only to intact skin. ( 2.1 ) Do not exceed the recommended dose of drug or duration of application. ( 2.1 ) Recommended duration of application ( 2.2 ): For dermal filler injection ablative laser facial resurfacing, or pulsed-dye laser therapy 20-30 minutes prior to procedure For superficial dermatological procedures such as laserassisted tattoo removal 60 minutes prior to procedure See Full Prescribing Information for amount to apply based upon treatment site surface area. ( 2.3 ) 2.1 Important Dosage and Administration Instructions For use in adults only. Lidocaine and tetracaine cream should only be applied to intact skin. Lidocaine and tetracaine cream should not be applied to a procedure site after the procedure has been performed. Remove lidocaine and tetracaine cream if skin irritation or a burning sensation occurs during application. In order to minimize the risk of systemic toxicity, do not exceed the recommended amount of drug to apply or the duration of the application [see Overdosage (10) ] . Avoid eye and lip contact with lidocaine and tetracaine cream. Wash hands after handling lidocaine and tetracaine cream. Upon removal from the treatment site, discard the used lidocaine and tetracaine cream in a location that is out of the reach of children and pets. Access to lidocaine and tetracaine cream by children or pets should be prevented during usage and storage of the product [see Warnings and Precautions (5.2) ] . Use only as directed. 2.2 Recommended Dosing Duration For superficial dermatological procedures, such as dermal filler injection, non-ablative laser facial resurfacing, or pulsed-dye laser therapy, apply lidocaine and tetracaine cream to intact skin for 20 to 30 minutes prior to the procedure. See Table 1 for instructions on the amount to apply. For superficial dermatological procedures, such as laser-assisted tattoo removal, apply lidocaine and tetracaine cream to intact skin for 60 minutes prior to the procedure. See Table 1 for instructions on the amount to apply. 2.3 Recommended Dosage The dose of lidocaine and tetracaine cream that provides effective local dermal analgesia depends on the duration of the application. Although not specifically studied, a shorter duration of application may result in a less complete dermal analgesia or a shorter duration of adequate dermal analgesia. Determine the amount of drug to apply The amount (length) of lidocaine and tetracaine cream that should be dispensed is determined by the size of the area to be treated (see Table 1 ). Using the ruler on the applicator included in the carton, squeeze out and measure the amount of lidocaine and tetracaine cream that approximates the amount required to achieve proper coverage. Spread lidocaine and tetracaine cream evenly and thinly (approximately 1 mm or the thickness of a dime) across the treatment area using a flat-surfaced tool such as a metal spatula or tongue depressor. After waiting the required application time, remove the lidocaine and tetracaine cream by grasping a free-edge with your fingers and pulling it away from the skin. Table 1. Amount of Lidocaine and Tetracaine Cream According to Treatment Site Surface Area Surface Area of Treatment Site (inch 2 ) Length of Lidocaine and Tetracaine Cream for 1 mm Thickness (inch) Weight of Lidocaine and Tetracaine Cream Dispensed (g) 2 1 1 3 2 3 6 5 5 12 9 11 16 12 13 23 18 20 31 24 26 39 30 33 47 36 40 54 42 46 62 48 53