Drug Catalog - Product Detail
TRIMETHOPRIM,USP TB 100MG 100
| NDC | Mfr | Size | Str | Form |
|---|---|---|---|---|
| 00591-5571-01 | ACTAVIS PHARMA | 100 | 100MG | TABLET |
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Description
DESCRIPTION Trimethoprim is a synthetic antibacterial available as 100 mg tablets for oral administration. Trimethoprim is 5-[(3,4,5-trimethoxyphenyl) methyl]-2,4-pyrimidinediamine. It is a white to cream colored, odorless, bitter compound. The structural formula is represented below: C 14 H 18 N 4 O 3 M.W. 290.32 Trimethoprim tablets, USP, 100 mg contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate, sodium starch glycolate and stearic acid. Trimethoprim Structural Formula
How Supplied
HOW SUPPLIED Trimethoprim tablets, USP, 100 mg are scored, oval-shaped, white tablets imprinted DAN DAN and 5571 supplied in bottles of 100. Store at 20° to 25°C (68° to 77°F) in a dry place. [See USP Controlled Room Temperature]. Dispense in a tight, light-resistant container as defined in the USP with a child-resistant closure (as required).
Indications & Usage
INDICATIONS AND USAGE To reduce the development of drug-resistant bacteria and maintain the effectiveness of trimethoprim tablets, USP and other antibacterial drugs, trimethoprim tablets, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli , Proteus mirabilis , Klebsiella pneumoniae , Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus . Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.
Dosage and Administration
DOSAGE AND ADMINISTRATION The usual oral adult dosage is 100 mg of trimethoprim every 12 hours or 200 mg of trimethoprim (two 100 mg tablets) every 24 hours, each for 10 days. The use of trimethoprim in patients with a creatinine clearance of less than 15 mL/min is not recommended. For patients with a creatinine clearance of 15 to 30 mL/min, the dose should be 50 mg every 12 hours.